Rival Signals and Project Selection: Insights from the Drug Development Process

References

• Acemoglu D, Linn J (2004) Market size in innovation: Theory and evidence from the pharmaceutical industry. Quart. J. Econom. 119(3):1049–1090.Crossref, Google Scholar
• Ali A, Kalwani MU, Kovenock D (1993) Selecting product development projects: Pioneering vs. incremental innovation strategies. Management Sci. 39(3):255–274.Link, Google Scholar
• Arora A, Gambardella A, Magazzini L, Pammolli F (2009) A breath of fresh air? Firm type, scale, scope, and selection effects in drug development. Management Sci. 55(10):1638–1653.Link, Google Scholar
• Bhaskaran SR, Ramachandran K (2011) Managing technology selection and development risk in competitive environments. Production Oper. Management 20(4):541–555.Crossref, Google Scholar
• Bloom N, Schankerman M, Van Reenen J (2013) Identifying technology spillovers and product market rivalry. Econometrica 81(4):1347–1393.Crossref, Google Scholar
• Chan T, Nickerson JA, Owan H (2007) Strategic management of R&D pipelines with cospecialized investments and technology markets. Management Sci. 53(4):667–682.Link, Google Scholar
• Chao RO, Lichtendahl KC, Grushka-Cockayne Y (2014) Incentives in a stage-gate process. Production Oper. Management 23(8):1286–1298.Crossref, Google Scholar
• Cockburn I, Henderson R (1994) Racing to invest? The dynamics of competition in ethical drug discovery. J. Econom. Management Strategy 3(3):481–519.Crossref, Google Scholar
• Cockburn IM, Henderson RM (1998) Absorptive capacity, coauthoring behavior, and the organization of research in drug discovery. J. Indust. Econom. 46(2):157–182.Crossref, Google Scholar
• Cook D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G, Pangalos MN (2014) Lessons learned from the fate of Astrazeneca’s drug pipeline: A five-dimensional framework. Nature Rev. Drug Discovery 13(6):419–431.Crossref, Google Scholar
• Crama P, De Reyck B, Taneri N (2017) Licensing contracts: Control rights, options, and timing. Management Sci. 63(4):1131–1149.Link, Google Scholar
• Czarnitzki D, Kraft K (2004) An empirical test of the asymmetric models on innovative activity: Who invests more into R&D, the incumbent or the challenger? J. Econom. Behav. Organ. 54(2):153–173.Crossref, Google Scholar
• Deephouse DL (1999) To be different, or to be the same? It’s a question (and theory) of strategic balance. Strategic Management J. 20(2):147–166.Crossref, Google Scholar
• DiMasi JA, Grabowski HG, Hansen RW (2016) Innovation in the pharmaceutical industry: New estimates of R&D costs. J. Health Econom. 47:20–33.Crossref, Google Scholar
• DiMasi JA, Feldman L, Seckler A, Wilson A (2010) Trends in risks associated with new drug development: Success rates for investigational drugs. Clinical Pharmacology Therapeutics 87(3):272–277.Crossref, Google Scholar
• Ding M, Dong S, Eliashberg J, Gopalakrishnan A (2014) Portfolio management in new drug development. Ding M, Eliashberg J, Stremersch S, eds. Innovation and Marketing in the Pharmaceutical Industry: Emerging Practices, Research, and Policies (Springer, New York), 83–118.Crossref, Google Scholar
• Drakeman D, Oraiopoulos N (2020) The risk of de-risking innovation: Optimal R&D strategies in ambiguous environments. California Management Rev. 62(3):42–63.Crossref, Google Scholar
• Ettlie JE, Bridges WP, O’Keefe RD (1984) Organization strategy and structural differences for radical vs. incremental innovation. Management Sci. 30(6):682–695.Link, Google Scholar
• Fleming L, Sorenson O (2004) Science as a map in technological search. Strategic Management J. 25(8–9):909–928.Crossref, Google Scholar
• Furman JL, Kyle MK, Cockburn I, Henderson RM (2005) Public & private spillovers, location and the productivity of pharmaceutical research. Ann. Econom. Statist. 79/80:165–188.Google Scholar
• Gilbert RJ, Newbery DM (1982) Preemptive patenting and the persistence of monopoly. Amer. Econom. Rev. 72(3):514–526.Google Scholar
• Girotra K, Terwiesch C, Ulrich KT (2007) Valuing R&D projects in a portfolio: Evidence from the pharmaceutical industry. Management Sci. 53(9):1452–1466.Link, Google Scholar
• Girotra K, Terwiesch C, Ulrich KT (2010) Idea generation and the quality of the best idea. Management Sci. 56(4):591–605.Link, Google Scholar
• Griliches Z (1979) Issues in assessing the contribution of research and development to productivity growth. Bell J. Econom. 10(1):92–116.Crossref, Google Scholar
• Griliches Z (1992) The search for R&D spillovers. Scandinavian J. Econom. 94:S29–S47.Crossref, Google Scholar
• Gu L (2016) Product market competition, R&D investment, and stock returns. J. Financial Econom. 119(2):441–455.Crossref, Google Scholar
• Harris C, Vickers J (1987) Racing with uncertainty. Rev. Econom. Stud. 54(1):1–21.Crossref, Google Scholar
• Henderson R, Cockburn I (1996) Scale, scope, and spillovers: The determinants of research productivity in drug discovery. RAND J. Econom. 27(1):32–59.Crossref, Google Scholar
• Hermosilla M (2021) Rushed innovation: Evidence from drug licensing. Management Sci. 67(1):257–278.Link, Google Scholar
• Hsieh KY, Vermeulen F (2014) The structure of competition: How competition between one’s rivals influences imitative market entry. Organ. Sci. 25(1):299–319.Link, Google Scholar
• Hutchison-Krupat J, Kavadias S (2014) Strategic resource allocation: Top-down, bottom-up, and the value of strategic buckets. Management Sci. 61(2):391–412.Link, Google Scholar
• Jaffe AB (1986) Technological opportunity and spillovers of R&D: Evidence from firms’ patents, profits, and market value. Amer. Econom. Rev. 76(5):984–1001.Google Scholar
• Jaffe AB (1989) Characterizing the “technological position” of firms, with application to quantifying technological opportunity and research spillovers. Res. Policy 18(2):87–97.Crossref, Google Scholar
• Jain S, Ramdas K (2005) Up or out—or stay put? Product positioning in an evolving technology environment. Production Oper. Management 14(3):362–376.Crossref, Google Scholar
• Kavadias S, Chao RO (2007) Resource allocation and new product development portfolio management. Loch CH, Kavadias S, eds. Handbook of New Product Development Management (Elsevier, Amsterdam), 135–163.Google Scholar
• Kavadias S, Hutchison-Krupat J (2020) A framework for managing innovation. Druehl C, Elmaghraby W, eds. Pushing the Boundaries: Frontiers in Impactful OR/OM Research. INFORMS TutORials in Operations Research (INFORMS, Catonsville, MD), 202–228.Link, Google Scholar
• Kavadias S, Ulrich KT (2020) Innovation and new product development: Reflections and insights from the research published in the first 20 years of Manufacturing & Service Operations Management. Manufacturing Service Oper. Management 22(1):84–92.Link, Google Scholar
• Khanna T (1995) Racing behavior technological evolution in the high-end computer industry. Res. Policy 24(6):933–958.Crossref, Google Scholar
• Kornish LJ, Hutchison-Krupat J (2017) Research on idea generation and selection: Implications for management of technology. Production Oper. Management 26(4):633–651.Crossref, Google Scholar
• Krieger JL (2021) Trials and terminations: Learning from competitors’ R&D failures. Management Sci. 67(9):5525–5548.Link, Google Scholar
• Krishnan V, Ulrich KT (2001) Product development decisions: A review of the literature. Management Sci. 47(1):1–21.Link, Google Scholar
• LaMattina J (2011) Why taking “shots on goal” matters to R&D. Drug Truths (blog) (May 26), https://johnlamattina.wordpress.com/2011/05/26/why-taking-shots-on-goal-matters-to-rd/.Google Scholar
• Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, et al. (2012) A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490(7419):187–191.Crossref, Google Scholar
• Leiponen A, Helfat CE (2010) Innovation objectives, knowledge sources, and the benefits of breadth. Strategic Management J. 31(2):224–236.Crossref, Google Scholar
• Lerner J (1997) An empirical exploration of a technology race. RAND J. Econom. 28(2):228–247.Crossref, Google Scholar
• Ma P, Zemmel R (2002) Value of novelty? Nature Rev. Drug Discovery 1(8):571–572.Crossref, Google Scholar
• Mansfield E (1995) Academic research underlying industrial innovations: Sources, characteristics, and financing. Rev. Econom. Statist. 77(1):55–65.Crossref, Google Scholar
• Martin X, Swaminathan A, Mitchell W (1998) Organizational evolution in the interorganizational environment: Incentives and constraints on international expansion strategy. Admin. Sci. Quart. 43(3):566–601.Crossref, Google Scholar
• Oraiopoulos N, Kavadias S (2014) The path-dependent nature of R&D search: Implications for (and from) competition. Production Oper. Management 23(8):1450–1461.Crossref, Google Scholar
• Osborn AF (1960) Applied Imagination: Principles and Procedures of Creative Problem-solving, revised ed. (Scribner, New York).Google Scholar
• Paci R, Marrocu E, Usai S (2014) The complementary effects of proximity dimensions on knowledge spillovers. Spatial Econom. Anal. 9(1):9–30.Crossref, Google Scholar
• Pakes A, Schankerman M (1984) An exploration into the determinants of research intensity. Griliches Z, ed. R&D, Patents and Productivity (University of Chicago Press, Chicago), 209–232.Google Scholar
• Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL (2010) How to improve R&D productivity: The pharmaceutical industry’s grand challenge. Nature Rev. Drug Discovery 9(3):203–214.Crossref, Google Scholar
• Pennetier C, Girotra K, Mihm J (2019) R&D spending: Dynamic or persistent? Manufacturing Service Oper. Management 21(3):636–657.Link, Google Scholar
• Reinganum JF (1983) Uncertain innovation and the persistence of monopoly. Amer. Econom. Rev. 73(4):741–748.Google Scholar
• Schlapp J, Oraiopoulos N, Mak V (2015) Resource allocation decisions under imperfect evaluation and organizational dynamics. Management Sci. 61(9):2139–2159.Link, Google Scholar
• Schmookler J (1966) Invention and Economic Growth (Harvard University Press, Cambridge, MA).Crossref, Google Scholar
• Semadeni M, Anderson BS (2010) The follower’s dilemma: Innovation and imitation in the professional services industry. Acad. Management J. 53(5):1175–1193.Crossref, Google Scholar
• Shane SA, Ulrich KT (2004) 50th anniversary article: Technological innovation, product development, and entrepreneurship in Management Science. Management Sci. 50(2):133–144.Link, Google Scholar
• Sommer SC, Bendoly E, Kavadias S (2020) How do you search for the best alternative? Experimental evidence on search strategies to solve complex problems. Management Sci. 66(3):1395–1420.Link, Google Scholar
• Stevens GA, Burley J (1997) 3,000 raw ideas = 1 commercial success! Res. Tech. Management 40(3):16–27.Crossref, Google Scholar
• Taneri N, De Meyer A (2017) Contract theory: Impact on biopharmaceutical alliance structure and performance. Manufacturing Service Oper. Management 19(3):453–471.Link, Google Scholar
• Thomke S, Kuemmerle W (2002) Asset accumulation, interdependence and technological change: Evidence from pharmaceutical drug discovery. Strategic Management J. 23(7):619–635.Crossref, Google Scholar
• Van de Ven WP, Van Praag BM (1981) The demand for deductibles in private health insurance: A probit model with sample selection. J. Econometrics 17(2):229–252.Crossref, Google Scholar
• Williams R (2012) Using the margins command to estimate and interpret adjusted predictions and marginal effects. Stata J. 12(2):308–331.Crossref, Google Scholar
• Zizzo DJ (2002) Racing with uncertainty: A patent race experiment. Internat. J. Indust. Organ. 20(6):877–902.Crossref, Google Scholar
• Zschocke MS, Mantin B, Jewkes EM (2014) The effect of competition on R&D portfolio investments. Production Oper. Management 23(8):1439–1449.Crossref, Google Scholar