The authors are grateful for the help of a number of project team members at the Duke Cancer Institute, including Chad Seastrunk, William T. Fulkerson, Craig Johnson, Nancy Hedrick, Celia Walsh, Steve Power, the pharmacy staff, and the nursing staff. The authors would like to thank Bjorn Berg for helpful comments during the preparation of this manuscript. The authors would also like to thank Randy Robinson, Alice Mack, and anonymous reviewers for their help in improving the final version of this manuscript. The authors are grateful for funding from Duke University Hospital to complete this project. This paper is also based in part upon work supported by the National Science Foundation [Grant CMMI 0844511]. Any opinions, findings, conclusions, or recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the National Science Foundation.