Portfolio-Wide Optimization of Pharmaceutical R&D Activities Using Mathematical Programming

Published Online:https://doi.org/10.1287/inte.2021.1074

References

  • Artigues C (2017) On the strength of time-indexed formulations for the resource-constrained project scheduling problem. Oper. Res. Lett. 45(2):154–159.Google Scholar
  • Artigues C, Koné O, Lopez P, Mongeau M (2015) Mixed-integer linear programming formulations. Schwindt C, Zimmermann J, eds. Handbook on Project Management and Scheduling, vol 1 (Springer, Cham, Switzerland), 17–41.Google Scholar
  • Bartels JH, Zimmermann J (2009) Scheduling tests in automotive R&D projects. Eur. J. Oper. Res. 193(3):805–819.Google Scholar
  • Beşikci U, Bilge Ü, Ulusoy G (2013) Resource dedication problem in a multi-project environment. Flexible Serv. Manufacturing J. 25(1-2):206–229.Google Scholar
  • Böttcher J, Drexl A, Kolisch R, Salewski F (1999) Project scheduling under partially renewable resource constraints. Management Sci. 45(4):543–559.LinkGoogle Scholar
  • Cha M, Yu F (2014) Pharma’s first-to-market advantage. McKinsey & Company (September 1), https://www.mckinsey.com/industries/pharmaceuticals-and-medical-products/our-insights/pharmas-first-to-market-advantage.Google Scholar
  • Chen J, Askin RG (2009) Project selection, scheduling and resource allocation with time dependent returns. Eur. J. Oper. Res. 193(1):23–34.Google Scholar
  • Colvin M, Maravelias CT (2008) A stochastic programming approach for clinical trial planning in new drug development. Comput. Chemical Engrg. 32(11):2626–2642.Google Scholar
  • Colvin M, Maravelias CT (2009) Scheduling of testing tasks and resource planning in new product development using stochastic programming. Comput. Chemical Engrg. 33(5):964–976.Google Scholar
  • Colvin M, Maravelias CT (2011) R&D pipeline management: Task interdependencies and risk management. Eur. J. Oper. Res. 215(3):616–628.Google Scholar
  • Deckro RF, Winkofsky E, Hebert JE, Gagnon R (1991) A decomposition approach to multi-project scheduling. Eur. J. Oper. Res. 51(1):110–118.Google Scholar
  • Demeulemeester EL, Herroelen WS (1997) A branch-and-bound procedure for the generalized resource-constrained project scheduling problem. Oper. Res. 45(2):201–212.LinkGoogle Scholar
  • Gruber TR (1993) A translation approach to portable ontology specifications. Knowledge Acquisition 5(2):199–220.Google Scholar
  • Hartmann S, Briskorn D (2010) A survey of variants and extensions of the resource-constrained project scheduling problem. Eur. J. Oper. Res. 207(1):1–14.Google Scholar
  • Hill A, Lalla-Ruiz E, Voß S, Goycoolea M (2019) A multi-mode resource-constrained project scheduling reformulation for the waterway ship scheduling problem. J. Scheduling 22(2):173–182.Google Scholar
  • Jain V, Grossmann IE (1999) Resource-constrained scheduling of tests in new product development. Indust. Engrg. Chemical Res. 38(8):3013–3026.Google Scholar
  • Kelley JE Jr (1961) Critical-path planning and scheduling: Mathematical basis. Oper. Res. 9(3):296–320.LinkGoogle Scholar
  • Kolisch R, Meyer K (2006) Selection and scheduling of pharmaceutical research projects. Józefowska J, Weglarz J, eds. Perspectives in Modern Project Scheduling (Springer, Boston), 321–344.Google Scholar
  • Lorenzoni LL, Ahonen H, de Alvarenga AG (2006) A multi-mode resource-constrained scheduling problem in the context of port operations. Comput. Indust. Engrg. 50(1-2):55–65.Google Scholar
  • Mavrotas G (2009) Effective implementation of the ε-constraint method in multi-objective mathematical programming problems. Appl. Math. Comput. 213(2):455–465.Google Scholar
  • Poppenborg J, Knust S (2016) Modeling and optimizing the evacuation of hospitals based on the MRCPSP with resource transfers. EURO J. Comput. Optim. 4(3):349–380.Google Scholar
  • Riise A, Mannino C, Burke EK (2016) Modelling and solving generalised operational surgery scheduling problems. Comput. Oper. Res. 66:1–11.Google Scholar
  • Schwindt C, Zimmermann J, eds. (2015a) Handbook on Project Management and Scheduling, vol. 1. (Springer, Cham, Switzerland).Google Scholar
  • Schwindt C, Zimmermann J, eds. (2015b) Handbook on Project Management and Scheduling, vol. 2. (Springer, Cham, Switzerland).Google Scholar
  • Shah N (2004) Pharmaceutical supply chains: Key issues and strategies for optimisation. Comput. Chemical Engrg. 28(6-7):929–941.Google Scholar
  • Talbot FB (1982) Resource-constrained project scheduling with time-resource tradeoffs: The nonpreemptive case. Management Sci. 28(10):1197–1210.LinkGoogle Scholar
  • Tiwari V, Patterson JH, Mabert VA (2009) Scheduling projects with heterogeneous resources to meet time and quality objectives. Eur. J. Oper. Res. 193(3):780–790.Google Scholar
  • Varma VA, Pekny JF, Blau GE, Reklaitis GV (2008) A framework for addressing stochastic and combinatorial aspects of scheduling and resource allocation in pharmaceutical R&D pipelines. Comput. Chemical Engrg. 32(4-5):1000–1015.Google Scholar
  • Varma VA, Reklaitis GV, Blau GE, Pekny JF (2007) Enterprise-wide modeling & optimization—an overview of emerging research challenges and opportunities. Comput. Chemical Engrg. 31(5-6):692–711.Google Scholar
  • Viswanath S, Guntz S, Dieringer J, Vaidyaraman S, Wang H, Gounaris CE (2021) An ontology to describe small molecule pharmaceutical product development and methodology for optimal activity scheduling. J. Pharmaceutical Innovation. Forthcoming.Google Scholar
  • Voß S, Witt A (2007) Hybrid flow shop scheduling as a multi-mode multi-project scheduling problem with batching requirements: A real-world application. Internat. J. Production. Econom. 105(2):445–458.Google Scholar
  • Wang H, Lappas NH, Gounaris CE (2019) Multi-mode resource constrained project scheduling with alternative prerequisites: New models and computational studies. Indust. Engrg. Chemical Res. 58(39):18253–18266.Google Scholar
  • Watermeyer K, Zimmermann J (2020) A branch-and-bound procedure for the resource-constrained project scheduling problem with partially renewable resources and general temporal constraints. OR Spectrum 42(2):427–460.Google Scholar
  • Weglarz J (1981) Project scheduling with continuously-divisible, doubly constrained resources. Management Sci. 27(9):1040–1053.LinkGoogle Scholar
  • Zapata JC, Hodge BM, Reklaitis GV (2008a) The multimode resource constrained multiproject scheduling problem: Alternative formulations. AIChE J. 54(8):2101–2119.Google Scholar
  • Zapata JC, Varma VA, Reklaitis GV (2008b) Impact of tactical and operational policies in the selection of a new product portfolio. Comput. Chemical Engrg. 32(1-2):307–319.Google Scholar
INFORMS site uses cookies to store information on your computer. Some are essential to make our site work; Others help us improve the user experience. By using this site, you consent to the placement of these cookies. Please read our Privacy Statement to learn more.