Application-Specific R&D Capabilities and the Advantage of Incumbents: Evidence from the Anticancer Drug Market
Published Online:26 Jun 2009https://doi.org/10.1287/mnsc.1090.1027
References
- American Cancer Society Cancer facts & figures. (2000) . Accessed March 10, 2008, http://www.cancer.org/downloads/STT/F&F00.pdfGoogle Scholar
- Strategic assets and organizational rent. Strategic Management J. (1993) 14(1):33–46Crossref, Google Scholar
- Combustion lean limits fundamentals and their application to a SI hydrogen-enhanced engine concept. (2006) . Unpublished doctoral dissertation, Massachusetts Institute of Technology, CambridgeGoogle Scholar
- Capturing knowledge within and across firm boundaries: Evidence from clinical development. Amer. Econom. Rev. (2004) 94(5):1591–1612Crossref, Google Scholar
- Firm resources and sustained competitive advantage. J. Management (1991) 17(1):99–120Crossref, Google Scholar
- Bear Sterns Biotechnology: Cancer—Concepts and controversies, Volume 1. (2002) . Report, Bear Sterns, New YorkGoogle Scholar
- Glivec (STI571, Imanitib), a rationally developed, targeted anticancer drug. Nature Rev. Drug Discovery (2002) 1:493–502Crossref, Google Scholar
- The Fates of de novo and de alio producers in the american automobile industry 1885–1981. Strategic Management J. (1996) 17(Special Issue):117–137Google Scholar
- Timeline: Chemotherapy and the war on cancer. Nature Rev. Cancer (2005) 5:65–72Crossref, Google Scholar
- The Innovator's Dilemma (1997) (Harvard Business School Press, Boston) Google Scholar
- Strategies for product cannibalism. Strategic Management J. (1988) 9(Special Issue):9–26Crossref, Google Scholar
- Strategic responses to technological threats. Bus. Horizons (1976) 19(1):61–69Crossref, Google Scholar
- Assets accumulation and sustainability of competition advantage. Management Sci. (1989) 35(12):1504–1514Link, Google Scholar
- The impact of patenting on new product introductions in the pharmaceutical industry. (2007) . Working paper, Georgia Institute of Technology, AtlantaCrossref, Google Scholar
- Organizational scope and investment: Evidence from the drug development strategies and performance of biopharmaceutical firms. (2004) . NBER Working Paper 10933, National Bureau of Economic Research, Cambrige, MACrossref, Google Scholar
- Know-how and asset complementarity and dynamic capability accumulation: The case of R&D. Strategic Management J. (1997) 18(5):339–360Crossref, Google Scholar
- Underinvestment and incompetence as responses to radical innovation—Evidence from the photolithographic alignment equipment industry. RAND J. Econom. (1993) 24(2):248–270Crossref, Google Scholar
- Of life-cycles real and imaginary—The unexpectedly long old-age of optical lithography. Res. Policy (1995) 24(4):631–643Crossref, Google Scholar
- Architectural innovation: The reconfiguration of existing product technologies and the failure of established firms. Admin. Sci. Quart. (1990) 35(1):9–30Crossref, Google Scholar
- , Mowery D. C., Nelson R. R. The pharmaceutical industry and the revolution in molecular biology: Interactions among scientific, institutional, and organizational change. Sources of Industrial Leadership (1999) (Cambridge University Press, Cambridge, UK) 267–311Crossref, Google Scholar
- International Business Machines (IBM) History of IBM. () . Accessed November 4, 2005, http://www-03.ibm.com/ibm/history/history/history_intro.htmlGoogle Scholar
- Dominance by birthright: Entry of prior radio producers and competitive ramifications in the US television receiver industry. Strategic Management J. (2000) 21(10/11):997–1016Crossref, Google Scholar
- The early history of radiotherapy: 1895–1939. Internat. J. Radiation Oncology, Biol., Phys. (1981) 7(5):639–648Crossref, Google Scholar
- Strategic pricing of new pharmaceuticals. Rev. Econom. Statist. (1998) 80(1):108–118Crossref, Google Scholar
- Limited Dependent and Qualitative Variables in Econometrics (1983) (Cambridge University Press, Cambridge, UK) Crossref, Google Scholar
- Toward a synthesis of the resource-based and dynamic-capability views of rent creation. Strategic Management J. (2001) 22:387–401Crossref, Google Scholar
- The underemphasized role of established firms as the sources of major innovations. Indust. Corporate Change (1996) 5(4):1181–1203Crossref, Google Scholar
- The dynamics of evolving markets: The effects of business sales and age on dissolutions and divestitures. Admin. Sci. Quart. (1994) 39(4):575–602Crossref, Google Scholar
- Diversified expansion by large established firms. J. Econom. Behav. Organ. (1991) 15:71–89Crossref, Google Scholar
- Diversification, ricardian rents, and Tobin's Q. RAND J. Econom. (1988) 19(4):623–632Crossref, Google Scholar
- Nature Nature milestones: DNA technologies. (2007) . Accessed April 24, 2009, http://www.nature.com/milestones/miledna/timeline.htmlGoogle Scholar
- Nature Reviews Cancer Nature milestones: Cancer. (2006) . Accessed April 24, 2009, http://www.nature.com/milestones/milecancer/timeline.htmlGoogle Scholar
- The Emergence of Biotechnology: Institutions and Markets in Industrial Innovation (1989) (Pinter Publishers, London) Google Scholar
- Econometric methods for fractional response variables with an application to 401(k) plan participation rates. J. Appl. Econometrics (1996) 11:619–632Crossref, Google Scholar
- , Rang H. P. The drug discovery process: General principles and some case histories. Drug Discovery and Development: Technology in Transition (2006) (Churchill Livingstone, London) 43–56Google Scholar
- Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials. J. Amer. Medical Assoc. (2004) 292(17):2130–2140Crossref, Google Scholar
- Incumbent's advantage through exploiting complementary assets via interfirm cooperation. Strategic Management J. (2001) 22(6/7):687–699Crossref, Google Scholar
- Diversification strategy and profitability. Strategic Management J. (1982) 3:359–369Crossref, Google Scholar
- The Theory of Economic Development (1934) (Harvard University Press, Cambridge, MA) Google Scholar
- Capitalism, Socialism and Democracy (1950) 3rd ed.(Harper, New York) Google Scholar
- PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene (2007) 26(21):3020–3026Crossref, Google Scholar
- Analyzing censored and sample-selected data with tobit and heckit models. Political Anal. (1999) 8(2):167–182Crossref, Google Scholar
- Technological resources and the direction of corporate diversification: Toward an integration of the resource-based view and transaction cost economics. Management Sci. (1999) 45(8):1109–1124Link, Google Scholar
- Decoupling market incumbency from organizational experience: A study of biotechnology's impact on the market for anti-cancer drugs. (2006) . Unpublished doctoral dissertation, Massachusetts Institute of Technology, Cambridge, MAGoogle Scholar
- Stephens Inc.Cancer, Revolutionary Therapies, Innovative Investment Opportunities (2002) 2nd ed.(Stephens Inc., Little Rock, AR) Google Scholar
- Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy. Res. Policy (1986) 15:285–305Crossref, Google Scholar
- Dynamic capabilities and strategic management. Strategic Management J. (1997) 18(7):509–533Crossref, Google Scholar
- Unraveling the process of creative destruction: Complementary assets and incumbent survival in the typesetter industry. Strategic Management J. (1997) 18:119–142Crossref, Google Scholar
- Technological discontinuities and organizational environments. Admin. Sci. Quart. (1986) 31(3):439–465Crossref, Google Scholar
- UBS Warburg The Cancer Matrix: Exploring the Future of Cancer Therapy. (2001) (UBS Warburg, Zurich) Google Scholar
- Mastering the Dynamics of Innovation (1994) (Harvard Business School Press, Boston) Google Scholar
- Racing to the Beginning of the Road: The Search for the Origin of Cancer (1996) (W. H. Freeman and Company, New York) Google Scholar
- Understanding dynamic capabilities. Strategic Management J. (2003) 24:991–995Crossref, Google Scholar
- Historic milestones in curative chemotherapy. Seminars in Oncology (1979) 6(4):490–505Google Scholar

