Dynamic Learning of Patient Response Types: An Application to Treating Chronic Diseases
Published Online:21 Aug 2017https://doi.org/10.1287/mnsc.2017.2793
References
- (2016) Response-adaptive designs for clinical trials: Simultaneous learning from multiple patients. Eur. J. Oper. Res. 248(2):619–633.Crossref, Google Scholar
- (2012) Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy. Statist. Medicine 31(17):1887–1902.Crossref, Google Scholar
- (2014) United States life tables, 2010. Natl. Vital Statist. Rep. 63(7), http://www.cdc.gov/nchs/data/nvsr/nvsr63/nvsr63_07.pdf.Google Scholar
- (2007) On Gittins’ index theorem in continuous time. Stochastic Processes Their Appl. 117(9):1357–1371.Crossref, Google Scholar
- (1978) Modified two-armed bandit strategies for certain clinical trials. J. Amer. Statist. Assoc. 73(362):339–345.Crossref, Google Scholar
- (1985) Bandit Problems: Sequential Allocation of Experiments (Chapman and Hall, London).Crossref, Google Scholar
- (1985) Optimal designs for clinical trials with dichotomous responses. Statist. Medicine 4(4):497–450.Crossref, Google Scholar
- (2016) An analytics approach to designing combination chemotherapy regimens for cancer. Management Sci. 62(5):1511–1531.Link, Google Scholar
- (2009) Multiple sclerosis risk sharing scheme: Two year results of clinical cohort study with historical comparator. BMJ 339:b4677.Crossref, Google Scholar
- (1999) Strategic experimentation. Econometrica 67(2):349–374.Crossref, Google Scholar
- (2010) Oral therapy for multiple sclerosis—Sea change or incremental step? New England J. Medicine 362(5):456–458.Crossref, Google Scholar
- (2015) Google, Biogen seek reasons for advance of multiple sclerosis. Bloomberg (January 27), http://www.bloomberg.com/news/articles/2015-01-27/google-biogen-seek-reasons-for-advance-of-multiple-sclerosis.Google Scholar
- (2013) Bandit problems with Lévy processes. Math. Oper. Res. 38(1):92–107.Link, Google Scholar
- (2004) Identifying and treating patients with suboptimal responses. Neurology 63(12, Suppl. 6):S33–S40.Crossref, Google Scholar
- (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. New England J. Medicine 362(5):402–415.Crossref, Google Scholar
- (2009) Optimizing the start time of statin therapy for patients with diabetes. Medical Decision Making 29(3):351–367.Crossref, Google Scholar
- (2012) Personalized medicine in multiple sclerosis: Hope or reality? BMC Medicine 10(1):116.Crossref, Google Scholar
- (2005) Methods for the Economic Evaluation of Health Care Programmes (Oxford University Press, Oxford, UK).Google Scholar
- (1994) Dynamic allocation problems in continuous time. Ann. Appl. Probab. 4(2):255–286.Crossref, Google Scholar
- (1996) Cost-Effectiveness in Health and Medicine (Oxford University Press, New York).Crossref, Google Scholar
- (2015) Investment timing with incomplete information and multiple means of learning. Oper. Res. 62(2):442–457.Link, Google Scholar
- (2015) The cost of multiple sclerosis drugs in the us and the pharmaceutical industry too big to fail? Neurology 84(21):2185–2192.Crossref, Google Scholar
- (2015) Dynamic forecasting and control algorithms of glaucoma progression for clinician decision support. Oper. Res. 63(5):979–999.Link, Google Scholar
- (2012) Early predictors of non-response to interferon in multiple sclerosis. Acta Neurologica Scandinavica 126(6):390–397.Crossref, Google Scholar
- (2014) Decision Making in Health and Medicine: Integrating Evidence and Values (Cambridge University Press, Cambridge, UK).Crossref, Google Scholar
- (2010) Strategic experimentation with Poisson bandits. Theor. Econom. 5(2):275–311.Crossref, Google Scholar
- (2015) Breakdowns. Theor. Econom. 10(1):175–202.Crossref, Google Scholar
- (2005) Strategic experimentation with exponential bandits. Econometrica 73(1):39–68.Crossref, Google Scholar
- (2006) The natural history of multiple sclerosis: A geographically based study—9: Observations on the progressive phase of the disease. Brain 129(3):584–594.Crossref, Google Scholar
- (2012) Cost-effectiveness of fingolimod versus interferon beta-1a for relapsing remitting multiple sclerosis in the United States. J. Medical Econom. 15(6):1088–1096.Crossref, Google Scholar
- (1987) Continuous multi-armed bandits and multiparameter processes. Ann. Probab. 15(4):1527–1556.Crossref, Google Scholar
- (2011) Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: A systematic review and meta-analysis. Ann. Rheumatic Diseases 70(11):1895–1904.Crossref, Google Scholar
- (2014) Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients. Eur. J. Oper. Res. 233(3):727–738.Crossref, Google Scholar
- (2015) Remote tracking of walking activity in MS patients in a real-world setting. Neurology 84(14, Suppl. P3.209), https://patientslikeme_posters.s3.amazonaws.com/2015_Remote%20Tracking%20of%20Walking%20Activity% 20in%20MS%20Patients%20in%20Real%20World.pdf.Google Scholar
- (2005) An experimental design for the development of adaptive treatment strategies. Statist. Medicine 24(10):1455–1481.Crossref, Google Scholar
- (2003) Optimal dynamic treatment regimes. J. Roy. Statist. Soc. Ser. B Statist. Methodol. 65(2):331–355.Crossref, Google Scholar
- (2007) Customizing treatment to the patient: Adaptive treatment strategies. Drug Alcohol Dependence 88(Suppl. 2):S1–S3.Crossref, Google Scholar
- National Multiple Sclerosis Society (2004) Changing therapy in relapsing multiple sclerosis: Considerations and recommendations of a task force of the National Multiple Sclerosis Society. Expert opinion paper, http://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Clinical_Bulletin_Changing-Therapy-in-Relapsing-MS.pdf.Google Scholar
- National Multiple Sclerosis Society (2008) Disease management consensus statement. Expert opinion paper, http://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/ExpOp_Consensus.pdf.Google Scholar
- National Multiple Sclerosis Society (2017) Disease-modifying therapies for MS. http://stage.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Brochure-The-MS-Disease-Modifying-Medications.pdf.Google Scholar
- (2011) Cost-effectiveness of disease-modifying therapy for multiple sclerosis: A population-based study. Neurology 77(4):355–363.Crossref, Google Scholar
- Once Weekly Interferon for MS Study Group (OWIMS) (1999) Evidence of interferon β-1a dose response in relapsing-remitting MS: The OWIMS study. Neurology 53(4):679–686.Crossref, Google Scholar
- (2005) Stopping beta-interferon therapy in multiple sclerosis: An analysis of stopping patterns. Multiple Sclerosis 11(1):46–50.Crossref, Google Scholar
- (2004) The cost of multiple sclerosis and the cost effectiveness of disease-modifying agents in its treatment. CNS Drugs 18(9):561–574.Crossref, Google Scholar
- (1984) Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheumatism 27(8):864–872.Crossref, Google Scholar
- (2007) Constructing evidence-based treatment strategies using methods from computer science. Drug Alcohol Dependence 88(Suppl. 2):S52–S60.Crossref, Google Scholar
- (2012) Optimal Learning (John Wiley & Sons, Hoboken, NJ).Crossref, Google Scholar
- (2003) Patient and community preferences for treatments and health states in multiple sclerosis. Multiple Sclerosis 9(3):311–319.Crossref, Google Scholar
- (2004) Cost-effectiveness of interferon beta-1a, interferon beta-1b, and glatiramer acetate in newly diagnosed non-primary progressive multiple sclerosis. Value Health 7(5):554–568.Crossref, Google Scholar
- (2010) Multiple sclerosis risk sharing scheme: A costly failure. BMJ 340:c1672.Crossref, Google Scholar
- (2011) Multiple sclerosis: Current treatment algorithms. Current Opinion Neurol. 24(3):230–237.Crossref, Google Scholar
- (2013) Clinical and MRI predictors of response to interferon-beta and glatiramer acetate in relapsing–remitting multiple sclerosis patients. Eur. J. Neurol. 20(7):1060–1067.Crossref, Google Scholar
- (2001) Short-term brain volume change in relapsing–remitting multiple sclerosis: Effect of glatiramer acetate and implications. Brain 124(9): 1803–1812.Crossref, Google Scholar
- (2006) Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. New England J. Medicine 354(9):911–923.Crossref, Google Scholar
- (2010) The natural history of multiple sclerosis, a geographically based study 10: Relapses and long-term disability. Brain 133(7):1914–1929.Crossref, Google Scholar
- (2003) Problems with UK government’s risk sharing scheme for assessing drugs for multiple sclerosis. British Medical J. 326(7385):388–392.Crossref, Google Scholar
- (2009) Cost-effectiveness of disease-modifying therapies in the management of multiple sclerosis for the Medicare population. Value Health 12(5):657–665.Crossref, Google Scholar
- (2010) The Healthcare Imperative: Lowering Costs and Improving Outcomes: Workshop Series Summary (National Academies Press, Washington, DC).Google Scholar
- (2012) Optimization of prostate biopsy referral decisions. Manufacturing Service Oper. Management 14(4):529–547.Link, Google Scholar

