A Novel Adaptive Testing Scheme for Multidisease Testing

References

• Aprahamian H, El-Amine H (2022) Optimal screening of populations with heterogeneous risk profiles under the availability of multiple tests. INFORMS J. Comput. 34(1):150–164. Link, Google Scholar
• Aprahamian H, Bish DR, Bish EK (2020) Optimal group testing: Structural properties and robust solutions, with application to public health screening. INFORMS J. Comput. 32(4):895–911.Abstract, Google Scholar
• Beckmann C, Hirsch HH (2016) Comparing Luminex NxTAG-Respiratory Pathogen Panel and RespiFinder-22 for multiplex detection of respiratory pathogens. J. Medical Virology 88(8):1319–1324.Crossref, Google Scholar
• BioMérieux (2025) BIOFIRE® FILMARRAY® Multiplex PCR System. Accessed April 12, 2025, https://www.biomerieux.com/us/en/our-offer/clinical-products/biofire-filmarray.html.Google Scholar
• BioSearch Technologies (2015) How much is your qPCR assay really costing you? Accessed September 1, 2024, https://blog.biosearchtech.com/how-much-is-your-qpcr-assay-really-costing-you.Google Scholar
• Bish DR, Bish EK, El Hajj H (2024) Disease bundling or specimen bundling? Cost- and capacity-efficient strategies for multidisease testing with genetic assays. Manufacturing Service Oper. Management 26(1):95–116.Link, Google Scholar
• Bish DR, Bish EK, El Hajj H, Aprahamian H (2021) A robust pooled testing approach to expand COVID-19 screening capacity. PLoS One 16(2):e0246285.Crossref, Google Scholar
• Centers for Disease Control and Prevention (2026) Data.CDC.gov: CDC open data portal. Accessed February 3, 2026, https://data.cdc.gov.Google Scholar
• Dorfman R (1943) The detection of defective members of large populations. Ann. Math. Statist. 14(4):436–440.Crossref, Google Scholar
• European Centre for Disease Prevention and Control (2020) Methodology for estimating point prevalence of SARS-CoV-2 infection by pooled RT-PCR testing. Accessed April 12, 2025, https://www.ecdc.europa.eu/sites/default/files/documents/Methodology-estimating-point-prevalence%20-SARS-CoV-2-infection-pooled-RT-PCR-testing.pdf.Google Scholar
• Ferkol T, Schraufnagel D (2014) The global burden of respiratory disease. Ann. Amer. Thoracic Soc. 11(3):404–406.Crossref, Google Scholar
• Garey MR, Johnson DS (1990) A Guide to the Theory of NP-completeness: Computers and Intractability (W H Freeman and Co., New York).Google Scholar
• Gibbs RA (1990) DNA amplification by the polymerase chain-reaction. Anal. Chemistry 62(13):1202–1214.Crossref, Google Scholar
• Gonsalves S, Mahony J, Rao A, Dunbar S, Juretschko S (2019) Multiplexed detection and identification of respiratory pathogens using the NxTAG® respiratory pathogen panel. Methods 158:61–68.Crossref, Google Scholar
• Hitt BD, Bilder CR, Tebbs JM, McMahan CS (2019) The objective function controversy for group testing: Much ado about nothing? Statist. Medicine 38(24):4912–4923.Crossref, Google Scholar
• Hou P, Tebbs JM, Bilder CR, McMahan CS (2017) Hierarchical group testing for multiple infections. Biometrics 73(2):656–665.Crossref, Google Scholar
• Hou P, Tebbs JM, Wang D, McMahan CS, Bilder CR (2020) Array testing for multiplex assays. Biostatistics 21(3):417–431.Crossref, Google Scholar
• Hudgens MG, Kim HY (2011) Optimal configuration of a square array group testing algorithm. Comm. Statist.: Theory Methods 40(3):436–448.Crossref, Google Scholar
• Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, Cohen C, et al. (2018) Estimates of global seasonal influenza-associated respiratory mortality: A modelling study. Lancet 391(10127):1285–1300.Crossref, Google Scholar
• Kay D (2025) Personal communication regarding the Wadsworth Center laboratory testing process [Telephone communication; exact date unknown]. Wadsworth Center, New York State Department of Health.Google Scholar
• Kim HY, Hudgens MG, Dreyfuss JM, Westreich DJ, Pilcher CD (2007) Comparison of group testing algorithms for case identification in the presence of test error. Biometrics 63(4):1152–1163.Crossref, Google Scholar
• Lin J, Wang D, Zheng Q (2019) Regression analysis and variable selection for two-stage multiple-infection group testing data. Statist. Medicine 38(23):4519–4533.Crossref, Google Scholar
• Mahony JB, Blackhouse G, Babwah J, Smieja M, Buracond S, Chong S, Ciccotelli W, et al. (2009) Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections. J. Clinical Microbiology 47(9):2812–2817.Crossref, Google Scholar
• McMahan CS, Tebbs JM, Bilder CR (2012) Informative Dorfman screening. Biometrics 68(1):287–296.Crossref, Google Scholar
• Nguyen N, Aprahamian H, Bish EK, Bish DR (2019) A methodology for deriving the sensitivity of pooled testing, based on viral load progression and pooling dilution. J. Translational Medicine 17(1):252.Crossref, Google Scholar
• Nouvellet P, Garske T, Mills HL, Nedjati-Gilani G, Hinsley W, Blake IM, Van Kerkhove MD, et al. (2015) The role of rapid diagnostics in managing Ebola epidemics. Nature 528(7580):S109–S116.Crossref, Google Scholar
• Schreckenberger PC, McAdam AJ (2015) Point-counterpoint: Large multiplex PCR panels should be first-line tests for detection of respiratory and intestinal pathogens. J. Clinical Microbiology 53(10):3110–3115.Crossref, Google Scholar
• Shams Eddin M, El-Amine H, Aprahamian H (2026) Optimal system adjustment under operational constraints with applications to infectious disease screening. INFORMS J. Comput. 38(2):357–376.Link, Google Scholar
• Shipitsyna E, Shalepo K, Savicheva A, Unemo M, Domeika M (2007) Pooling samples: The key to sensitive, specific and cost-effective genetic diagnosis of Chlamydia trachomatis in low-resource countries. Acta Dermato-Venereologica 87(2):140–143.Crossref, Google Scholar
• Stramer SL, Krysztof DE, Brodsky JP, Fickett TA, Reynolds B, Dodd RY, Kleinman SH (2013) Comparative analysis of triplex nucleic acid test assays in United States blood donors. Transfusion 53(10):2525–2537.Crossref, Google Scholar
• Tebbs JM, McMahan CS, Bilder CR (2013) Two-stage hierarchical group testing for multiple infections with application to the infertility prevention project. Biometrics 69(4):1064–1073.Crossref, Google Scholar
• Westreich DJ, Hudgens MG, Fiscus SA, Pilcher CD (2008) Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification tests. J. Clinical Microbiology 46(5):1785–1792.Crossref, Google Scholar